Could Julianne Moore finally win Oscar for 'Alice'?

In her latest movie, the radiant 54-year-old redhead plays a woman who has everything -- love, children and a career, but faces losing it all as she descends into the fog of dementia.

Moore already scooped up a Golden Globe for the role last weekend, on top of the one she won in 2013 for playing Republican vice presidential candidate Sarah Palin in the HBO film "Game Change" and a shared Globe for best ensemble cast in 1994 for "Short Cuts."

"Thank u everyone for the congratulations! i am so happy i can barely breathe," tweeted Moore, whose rivals in the best actress category include former Oscar winners Reese Witherspoon and France's Marion Cotillard, along with Britain's Felicity Jones and Rosamund Pike.

In "Still Alice," co-directed by married partners Richard Glatzer and Wash Westmoreland, Moore plays a woman who gradually loses that which defined her: her intellect, her ability to communicate, her memories.

She loses her ability to speak, no longer recognizes the building where she worked and cannot even find the bathroom in her own home. Her character eventually turns towards suicide.

But the film -- in which Alec Baldwin plays Moore's husband, and "Twilight" star Kristen Stewart and Kate Bosworth portray her daughters -- works through restraint, rather than through spectacle.

Moore says she did a lot of research for the role.

"I went to the Alzheimer's Association ... they set me up with women all around the US who had been diagnosed," she said.

The women told her how they felt marginalized, in particular after losing a job.

"It is so much a movie about life, love and mortality. And I'm looking a lot at mortality... when I went home, I was so happy to go home and have my husband and my children and my life, and my work," she said.

"And I really felt I could take the time to appreciate it... that was the gift of this movie to my life," she added, in a question and answer session organized after a screening hosted by industry journal Variety.

The actress -- who was first nominated for an Oscar in 1998, for "Boogie Nights" -- added: "What does it feel like, all of a sudden realizing the brevity of her time?

"How does it affect her relationships, how does it affect what she wants to do?"

Thursday's nomination is the first in more than a decade for Moore, who was shortlisted in 2000 for "The End of the Affair," and then earned a double nod in 2003 for "The Hours" and "Far From Heaven."

If she should win her first Oscar on February 22, you won't see her with any notes in hand.

"That looks so silly. You come up with a piece of paper and you're like, 'I knew it! I knew it!'" she told The Huffington Post after her Globes win for best actress in a drama -- besting three of her four Oscar rivals.