Exclusive: French health body to say mRNA vaccine should be used as second dose after AstraZeneca

Reuters had reported on Wednesday that the Haute Autorite de la Sante (HAS), in charge of setting out how vaccines approved by the European Medicines Agency (EMA) should be used in France, was contemplating this possibility.

The HAS has now decided to proceed with the plan, the two sources said. Two mRNA vaccines, one from Pfizer and BioNTech and one from Moderna, are approved for use in France.

Messenger RNA vaccines prompt the human body to make a protein that mimics part of the virus, triggering an immune response, while viral vector vaccines such as AstraZeneca's use a common cold virus to carry DNA instructions for doing the same thing.

An HAS spokeswoman had no comment.

Vaccination programmes have stuttered in Europe and elsewhere in the last month, since a very few mostly young recipients of the AstraZeneca shot were found to have suffered extremely unusual blood clots, leading some countries to suspend its use as a precaution.

Most have resumed using the shot, although some have done so with age restrictions.

In France, the HAS advised on March 19 that only people aged 55 and over should receive the AstraZeneca vaccine, which had already been given to 500,000 people as a first dose.

While the numbers are small compared with the tens of millions being inoculated across the EU, a decision to give a different booster shot would be significant because the approach has not been tested in late-stage human trials.