This means that any country among the ICC's 124 member states would be obliged to arrest Netanyahu and Gallant if they were to enter their territory.
ICC Chief Prosecutor Karim Khan had initially requested these warrants in May, asserting that Netanyahu and Gallant might be culpable for actions in Gaza that caused widespread starvation, amounting to war crimes and crimes against humanity.
On Thursday, the court said it had unanimously decided to reject Israel’s appeal over the ICC’s jurisdiction.
Other than those two, the Hague-based court also issued a warrant for Hamas leader Mohammed Deif, citing alleged war crimes linked to the Gaza conflict.
However, Israel said in August it had killed Deif in an air strike in Gaza a month earlier.