West Africa in desperate wait for Ebola aid

Liberia, the hardest-hit nation with almost 1,700 deaths, welcomed pledges of help from world leaders gathered at the United Nations on Thursday but warned it was losing the trust of its people as the crisis escalated.

"We are happy to hear that the entire world now understands the urgency of the reaction to threat of Ebola," Liberian Information Minister Lewis Brown told AFP.

"We hope that the commitment will be quickly followed by action because, if this drags for long, the populations of the various countries will begin to lose patience and they will blame our governments."

Health systems in Liberia, Sierra Leone and Guinea have been overwhelmed by the epidemic, which has killed 3,000 people since the start of the year, and are in dire need of doctors, nurses, medical equipment and supplies.

The WHO told reporters in Geneva it was working with British company GlaxoSmithKline (GSK) and American group NewLink Genetics to accelerate clinical trials on two vaccines.

Some trials of the GSK vaccine have begun in the United States and Britain, and others are expected to begin in Mali next week, said WHO assistant director general Marie-Paule Kieny.

Trials of the NewLink vaccine are also set to start "imminently" in the US, and others are planned in Germany and elsewhere.

"If everything goes well, we may be able to begin using some of these vaccines in some of the affected countries at the very beginning of next year," Kieny said.

Currently, there is no licenced treatment or vaccine against Ebola, although drugs which have not been fully tested have already been given to a few infected health workers, with stocks extremely limited.

"This is not a vaccine, this is a candidate vaccine," Kieny stressed, pointing to the need for caution in rolling out the vaccines.

The two prototypes "have given very promising results in monkeys, but monkeys are not humans", she said, adding that people who receive them initially "should not consider themselves protected against Ebola".

WHO is trying to accelerate the development of around half a dozen treatments for Ebola, including the prototype ZMapp drug already given to US and Spanish aid workers.

Kieny said "a few hundred doses" should be available by the end of the year.

US President Barack Obama led calls for a ramped up response to the Ebola epidemic at the UN in New York on Thursday, urging governments, businesses and international organisations to join the fight.

Officials could not provide an immediate tally of the total pledges made at the meeting but the UN's coordinator for Ebola, David Nabarro, said countries had "responded with generosity".

Canada announced a contribution of $27 million (21 million euros) while France said it had set aside 70 million euros in a battle that the United Nations estimates will require close to one billion dollars.

The European Union said it would add 30 million euros to the current 150 million euros it has provided.

But Obama warned: "We are not doing enough".

UN officials said a 20-fold surge in assistance is needed to come to grips with the outbreak.

- 'Battlefront' -

Sierra Leone took the drastic step on Thursday of putting another three of its 14 districts under quarantine, meaning that more than a third of the population of six million can no longer move freely.

"My country is at the battlefront of one of the biggest life and death challenges facing the global human community," Sierra Leone's President Ernest Bai Koroma warned the UN by video link from Freetown.

A UN mission on Ebola set up last week is due to deploy in west Africa on Sunday, bringing supplies and equipment including protective suits, trucks, helicopters and other aircraft.

The United States has begun sending the first of a 3,000-strong military mission to Liberia to help battle the contagion and has mobilised its experts from the Centres for Disease Control and Prevention to help beat back the virus.

Cuba said on Friday it would send nearly 300 more doctors and nurses to help fight epidemic, raising to 461 the number of its medical personnel in the region.

Meanwhile British actor Idris Elba, whose parents are from Sierra Leone, has joined the UN campaign to ramp up the response.

Elba, who portrayed Nelson Mandela in "Long Walk to Freedom", told journalists in New York the world was "setting up" the fight against Ebola, but that it will take time.