Nearly 40 people were injured, Yuvaraj said.
The blast took place on Wednesday at the 40-acre unit of privately held Escientia Advanced Sciences in the Anakapalli district. Government officials said they suspected there was an explosion in the chemical reactor.
Escientia did not immediately respond to a request for comment.
The state government has ordered an inquiry into the incident.
"Pained by the loss of lives due to a mishap at a factory in Anakapalli. Condolences to those who lost their near and dear ones," Prime Minister Narendra Modi said in a post on messaging platform X.
Known as the pharmacy of the world, India is home to many pharmaceuticals manufacturing plants.
At least two people were killed and five others injured in a similar incident last year, when a fire broke out at a solvent reactor of a unit of Sahithi Pharma in the same district.
