"Having failed to destroy the will of the resistance front, the Zionist regime (Israel) has put blind assassinations back on its agenda to save itself. It must know that it will never achieve its goals and that this cowardly crime will not go unanswered," Raisi said, according to state media.
Israel has long targeted Iran's military installations in Syria and those of its proxies, but Monday's attack was the first time it apparently hit the vast embassy compound itself. An Israeli military spokesperson declined to comment.
More than 32,000 Palestinians have been killed in Israel's offensive in Gaza, according to Palestinian health authorities.