Fifteen people were shot, one fatally, at a nightclub in Cincinnati, Ohio, early on Sunday, and police said they believed at least two shooters may have been involved.

The shooting took place around 1 a.m. when hundreds of people were reported at the Cameo Nightlife club, which the Cincinnati Police Department said has had "multiple problems" in the past.

"At this point it's unclear exactly what instigated the shooting," Captain Kimberly Williams said at a televised briefing.

"We believe that there were at least a couple of shooters involved. Just a lot of chaos when the shots went off," Williams added.

The suspects were at large and police do not have good descriptions of them, in part because witnesses were reluctant to cooperate, Williams told WCPO.

Several of the victims had life-threatening injuries, WLWT-TV reported on its website, quoting Assistant Police Chief Paul Neudigate, who said hundreds of people were in the nightclub at the time of shooting.

Authorities have said nothing yet about a possible motive for the shooting, which comes less than a year after a gunman opened fire at a gay nightclub in Orlando, Florida, killing 49 people. It was the deadliest mass shooting in U.S. history.

The University of Cincinnati Medical Center admitted eight people early Sunday, a spokeswoman told ABC News, but she did not say specifically whether the patients were connected to the nightclub shooting. A representative of the hospital could not be reached immediately for comment.

Cameo Nightlife's Facebook page says it features "College Friday's" for students 18 and older and "Saturday's 21+ grown and sexy night."