The "large-magnitude" landslide occurred in the center of the country in the city of Banos de Agua Santa, the Ecuadorean Secretariat for Risk Management said in a report.
"My solidarity with all the families that have been affected," wrote Roberto Luque, Ecuador's minister of public works, on the social media platform X.
A heavy rainstorm caused by low pressure swept across parts of Central and South America on Sunday, with various countries warning of the increased risk of landslides, rock falls and flooding.
In El Salvador, the country's civil protection agency declared a red alert due to heavy rains throughout the small nation, while in neighboring Guatemala several airlines diverted flights, according to the Guatemalan ministry of communications, infrastructure and housing.